The San Francisco 49ers vs Los Angeles Rams rivalry produced several memorable matchups in the 2025 NFL season, including two notable games: a 26–23 overtime victory for the 49ers in Week 5 and a 42–26 Rams win in Week 10. Below is a breakdown of player stats and standout performances from those contests to help you understand which players made the biggest impact.
Game 1: 49ers 26, Rams 23 (Week 5)
In the tight Thursday Night Football matchup, the 49ers edged the Rams 26–23 in overtime on October 2, 2025. Despite missing several key starters, San Francisco executed efficiently in clutch moments to secure the win.
Passing Leaders
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Mac Jones (49ers): Jones delivered an efficient performance, throwing for over 300 passing yards and multiple touchdowns, keeping San Francisco competitive despite roster challenges.
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Matthew Stafford (Rams): Stafford also had a strong outing, completing a significant portion of his passes and producing scoring opportunities for Los Angeles before overtime.
Key Notes:
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Both quarterbacks showed poise under pressure — Jones by engineering scoring drives without star receivers, and Stafford by keeping the Rams in striking range through the fourth quarter.
Rushing and Receiving Highlights
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Exact individual rushing totals for this game are not widely published, but both teams featured balanced ground attacks with multiple contributors.
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Receivers on both sides made key catches that kept drives alive. Notably, San Francisco’s depth players stepped up in the absence of top wideouts to help Jones sustain momentum.
Clutch Performances
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Eddy Pineiro (49ers): Kicker Pineiro drilled the decisive field goal in overtime to lift San Francisco to victory.
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49ers Defense: A crucial stop on fourth‑and‑1 late in overtime preserved the win, showcasing defensive resolve.
Game 2: Rams 42, 49ers 26 (Week 10)
In the later meeting on November 9, 2025, the Rams blew out the 49ers 42–26, with veteran quarterback Matthew Stafford leading a potent offensive performance.
Passing Leaders
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Matthew Stafford (Rams): Stafford threw four touchdown passes and amassed significant passing yardage, lifting Los Angeles’ scoring attack and showcasing his MVP‑caliber play.
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Mac Jones (49ers): Jones also threw for a score for San Francisco, but it wasn’t enough to keep pace with the Rams’ scoring output.
Key Notes:
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Stafford’s efficient passing and ability to find multiple targets allowed the Rams to build an early lead and sustain drives through the second half.
Rushing and Receiving Leaders
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Kyren Williams (Rams): Williams contributed significantly in both the ground and passing games, scoring at least one rushing touchdown and helping set up field position.
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Puka Nacua (Rams): Nacua scored on a long touchdown reception, showcasing his big‑play ability.
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Jauan Jennings (49ers): Jennings was one of San Francisco’s main receiving threats, hauling in a long touchdown pass from Jones.
Overall Team Stats (Week 10)
| Team | Total Points | Passing TDs | Rushing TDs | Key Contributors |
|---|---|---|---|---|
| Rams | 42 | 4 (Stafford) | Multiple (including Williams) | Stafford, Nacua, Williams |
| 49ers | 26 | 1 (Jones) | 1 (Jennings reception) | Jones, Jennings |
Data compiled from box scores and live stats summaries.
Standout Performances & Context
Matthew Stafford’s MVP‑Level Play
Stafford’s dominant Week 10 performance — including multiple touchdown passes — reflects his status as one of the league’s top quarterbacks. His ability to distribute the ball and avoid turnovers helped the Rams build a commanding lead.
Mac Jones’ Resilience
Despite missing key offensive weapons in Week 5 and facing a tough Rams defense in Week 10, Jones delivered solid passing stats in both games, showing growth and toughness under pressure.
Rising Stars in Skill Positions
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Rams Puka Nacua and Kyren Williams have both emerged as consistent offensive weapons, making explosive plays in the passing and rushing games.
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49ers receivers like Jauan Jennings stepped up in critical moments, accounting for touchdowns in both matchups.
Conclusion:
The 49ers vs Rams matchups in 2025 highlighted contrasting offensive styles:
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49ers: Relied on efficient quarterback play and timely field goals in close contests.
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Rams: Showcased explosive scoring with veteran leadership and dynamic playmakers in more decisive victories.
These matchups offered fans a clear look at how both teams’ key players impact game outcomes and provided rich stats for comparison across passing, rushing, and receiving — essential insights for analysis, fantasy football, and deeper NFL understanding.